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Phenotypes Associated with This Genotype
Genotype
MGI:3723178
Allelic
Composition		 Mrc1tm1Mnz/Mrc1tm1Mnz
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrc1tm1Mnz mutation (1 available); any Mrc1 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:124290 )
• migration distance and speed of bone marrow macrophages is increased compared to that of wild-type cells
• migration speed of bone marrow macrophages in response to colony stimulating factor-1 (CSF-1) is increased relative to that of wild-type cells
• however, membrane ruffling stimulated by CSF-1 is normal

hematopoietic system
abnormal macrophage physiology ( J:124290 )
• migration distance and speed of bone marrow macrophages is increased compared to that of wild-type cells
• migration speed of bone marrow macrophages in response to colony stimulating factor-1 (CSF-1) is increased relative to that of wild-type cells
• however, membrane ruffling stimulated by CSF-1 is normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory