Phenotypes for Cd19 Pax5 MGI:3720352 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Pax5^tm1Mbu/Pax5^tm3Mbu
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Pax5^tm1Mbu mutation (1 available); any Pax5 mutation (39 available)
Pax5^tm3Mbu mutation (1 available); any Pax5 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:75504 )

• LPS-stimulated lymph node B cells exhibit a low frequency of and a delay in increased cell size relative to wild-type cells

abnormal class switch recombination ( J:75504 )

• IgG class switching is decreased

decreased immature B cell number ( J:75504 )

• short-lived IgM-B220^lo and IgM+B220^lo immature B cells are slightly lower in number

decreased mature B cell number ( J:75504 )

• there is a 3-fold reduction in the number of long-lived mature B cells

• mice lack recirculating IgM+IgD+B220^hi cells in the bone marrow

decreased pre-B cell number ( J:75504 )

• short-lived IgM-B220^lo B cells are slightly lower in number

decreased immunoglobulin level ( J:75504 )

• total immunoglobin is reduced 3-fold compared to control mice

decreased IgG level ( J:75504 )

• IgG levels are decreased ranging from a 9.4-fold decrease of IgG1 to a 2-fold decrease in IgG3 levels

decreased IgG1 level ( J:75504 )

decreased IgG3 level ( J:75504 )

hematopoietic system

abnormal B cell differentiation ( J:75504 )

• LPS-stimulated lymph node B cells exhibit a low frequency of and a delay in increased cell size relative to wild-type cells

abnormal class switch recombination ( J:75504 )

• IgG class switching is decreased

decreased immature B cell number ( J:75504 )

• short-lived IgM-B220^lo and IgM+B220^lo immature B cells are slightly lower in number

decreased mature B cell number ( J:75504 )

• there is a 3-fold reduction in the number of long-lived mature B cells

• mice lack recirculating IgM+IgD+B220^hi cells in the bone marrow

decreased pre-B cell number ( J:75504 )

• short-lived IgM-B220^lo B cells are slightly lower in number

decreased immunoglobulin level ( J:75504 )

• total immunoglobin is reduced 3-fold compared to control mice

decreased IgG level ( J:75504 )

• IgG levels are decreased ranging from a 9.4-fold decrease of IgG1 to a 2-fold decrease in IgG3 levels

decreased IgG1 level ( J:75504 )

decreased IgG3 level ( J:75504 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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