About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3720352
cn5
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Pax5tm1Mbu/Pax5tm3Mbu
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Pax5tm1Mbu mutation (1 available); any Pax5 mutation (39 available)
Pax5tm3Mbu mutation (1 available); any Pax5 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• LPS-stimulated lymph node B cells exhibit a low frequency of and a delay in increased cell size relative to wild-type cells
• IgG class switching is decreased
• short-lived IgM-B220lo and IgM+B220lo immature B cells are slightly lower in number
• there is a 3-fold reduction in the number of long-lived mature B cells
• mice lack recirculating IgM+IgD+B220hi cells in the bone marrow
• short-lived IgM-B220lo B cells are slightly lower in number
• total immunoglobin is reduced 3-fold compared to control mice
• IgG levels are decreased ranging from a 9.4-fold decrease of IgG1 to a 2-fold decrease in IgG3 levels

hematopoietic system
• LPS-stimulated lymph node B cells exhibit a low frequency of and a delay in increased cell size relative to wild-type cells
• IgG class switching is decreased
• short-lived IgM-B220lo and IgM+B220lo immature B cells are slightly lower in number
• there is a 3-fold reduction in the number of long-lived mature B cells
• mice lack recirculating IgM+IgD+B220hi cells in the bone marrow
• short-lived IgM-B220lo B cells are slightly lower in number
• total immunoglobin is reduced 3-fold compared to control mice
• IgG levels are decreased ranging from a 9.4-fold decrease of IgG1 to a 2-fold decrease in IgG3 levels


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/18/2025
MGI 6.24
The Jackson Laboratory