immune system
• LPS-stimulated lymph node B cells exhibit a low frequency of and a delay in increased cell size relative to wild-type cells
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• IgG class switching is decreased
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• short-lived IgM-B220lo and IgM+B220lo immature B cells are slightly lower in number
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• there is a 3-fold reduction in the number of long-lived mature B cells
• mice lack recirculating IgM+IgD+B220hi cells in the bone marrow
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• short-lived IgM-B220lo B cells are slightly lower in number
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• total immunoglobin is reduced 3-fold compared to control mice
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• IgG levels are decreased ranging from a 9.4-fold decrease of IgG1 to a 2-fold decrease in IgG3 levels
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hematopoietic system
• LPS-stimulated lymph node B cells exhibit a low frequency of and a delay in increased cell size relative to wild-type cells
|
• IgG class switching is decreased
|
• short-lived IgM-B220lo and IgM+B220lo immature B cells are slightly lower in number
|
• there is a 3-fold reduction in the number of long-lived mature B cells
• mice lack recirculating IgM+IgD+B220hi cells in the bone marrow
|
• short-lived IgM-B220lo B cells are slightly lower in number
|
• total immunoglobin is reduced 3-fold compared to control mice
|
• IgG levels are decreased ranging from a 9.4-fold decrease of IgG1 to a 2-fold decrease in IgG3 levels
|