Phenotypes Associated with This Genotype

Genotype
MGI:3718580

• Allelic Composition: Tg(TRAMP)8247Ng/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histological analysis of prostate tumors in Tg(TRAMP)8247Ng/0 mice

neoplasm

increased prostate gland adenocarcinoma incidence ( J:65303 , J:217920 )

♂ • males display focal and invasive adenocarcinoma of the prostate by 20 weeks (J:65303)

♂ • mice exhibit a range of prostate hyperplasia to invasive carcinomas (J:217920)

♂ • mice treated with bromhexine hydrochloride, a TMPRSS2 inhibitor, at 15 weeks of age and continued to about 20 weeks, show larger prostate glands (ie, larger prostate tumors) than vehicle-treated mice and reduced incidence of distant metastasis to lung and liver from 55% in vehicle-treated mice to 20% with bromhexine hydrochloride (J:217920)

reproductive system

prostate gland hyperplasia ( J:65303 )

♂ • intraepithelial hyperplasia can be detected in males by 10 weeks of age and by 22 weeks of age, almost all prostatic glands are hyperplastic

increased prostate gland adenocarcinoma incidence ( J:65303 , J:217920 )

♂ • males display focal and invasive adenocarcinoma of the prostate by 20 weeks (J:65303)

♂ • mice exhibit a range of prostate hyperplasia to invasive carcinomas (J:217920)

♂ • mice treated with bromhexine hydrochloride, a TMPRSS2 inhibitor, at 15 weeks of age and continued to about 20 weeks, show larger prostate glands (ie, larger prostate tumors) than vehicle-treated mice and reduced incidence of distant metastasis to lung and liver from 55% in vehicle-treated mice to 20% with bromhexine hydrochloride (J:217920)

endocrine/exocrine glands

prostate gland hyperplasia ( J:65303 )

♂ • intraepithelial hyperplasia can be detected in males by 10 weeks of age and by 22 weeks of age, almost all prostatic glands are hyperplastic

increased prostate gland adenocarcinoma incidence ( J:65303 , J:217920 )

♂ • males display focal and invasive adenocarcinoma of the prostate by 20 weeks (J:65303)

♂ • mice exhibit a range of prostate hyperplasia to invasive carcinomas (J:217920)

♂ • mice treated with bromhexine hydrochloride, a TMPRSS2 inhibitor, at 15 weeks of age and continued to about 20 weeks, show larger prostate glands (ie, larger prostate tumors) than vehicle-treated mice and reduced incidence of distant metastasis to lung and liver from 55% in vehicle-treated mice to 20% with bromhexine hydrochloride (J:217920)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:65303