Phenotypes Associated with This Genotype

Genotype
MGI:3715183

hm1

• Allelic Composition: Mx1^s1/Mx1^s1
• Genetic Background: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:23752 )

• 14 of 16 mice die following infection with Thogoto virus

immune system

increased susceptibility to Orthomyxoviridae infection ( J:23752 )

• following Thogoto virus infection, titers of 10^7.5 are detected in 50% of tissues

• following Thogoto virus infection, livers become pale, yellow, swollen, and friable at 72 to 96 hours

• following Thogoto virus infection, cellular degeneration in the liver is characterized by acidophilic hyalinization of the cytoplasm, pyknotic, or karyorrhetic nuclei and the formation of typical Councilman bodies

• following Thogoto virus infection, liver necrosis occurs

• IFN treatment only slightly inhibits or delays Thogoto virus multiplication in embryo cells