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Phenotypes Associated with This Genotype
Genotype
MGI:3706955
cx16
Allelic
Composition		 Il6tm1Kopf/Il6tm1Kopf
Npc1m1N/Npc1m1N
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (10 available); any Il6 mutation (41 available)
Npc1m1N mutation (3 available); any Npc1 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal glial cell physiology ( J:118352 )
• nmber of activated microglial and astroglial cells is decreased in 6-week old mice compared to Il6-sufficient, Npc1-null mice

cellular
abnormal glial cell physiology ( J:118352 )
• nmber of activated microglial and astroglial cells is decreased in 6-week old mice compared to Il6-sufficient, Npc1-null mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory