Phenotypes Associated with This Genotype

Genotype
MGI:3700037

• Allelic Composition: Spry2^tm1Ayos/Spry2^tm1Ayos; Spry4^tm1Ayos/Spry4^tm1Ayos
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:116506 )

• most die by E12.5

prenatal lethality, complete penetrance ( J:116506 )

vision/eye

cyclopia ( J:116506 )

craniofacial

abnormal craniofacial morphology ( J:116506 )

• craniofacial abnormalities

limbs/digits/tail

abnormal limb morphology ( J:116506 )

• limb abnormalities

nervous system

abnormal brain development ( J:116506 )

abnormal forebrain development ( J:116506 )

• severe truncation of the forebrain and cephalic neural crest-derived head tissues

alobar holoprosencephaly ( J:116506 )

• alobar brain development and cyclopia resemble holoprosencephaly

respiratory system

abnormal lung development ( J:116506 )

• exhibit abnormalities of the lung pattern and epithelial branching

abnormal respiratory conducting tube morphology ( J:116506 )

• reduced number of airways

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acrocephalosyndactylia		DOID:12960	OMIM:101200	J:116506