Phenotypes Associated with This Genotype

Genotype
MGI:3697585

• Allelic Composition: Cr1l^tm1Hmo/Cr1l^tm1Hmo
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:197576 )

N • homozygotes from mothers that are treated with a blocking anti-C5 antibody throughout pregnancy survive to adulthood

lethality throughout fetal growth and development, complete penetrance ( J:59432 )

• normal frequency of homozygotes until around E9.5

• all are dead by E16.5

embryo

abnormal trophectoderm morphology ( J:59432 )

• C3 (complement) deposited on the surface

abnormal ectoplacental cone morphology ( J:59432 )

• C3 (complement) deposited on the surface

abnormal maternal decidual layer morphology ( J:59432 )

♀ • reduced deciduas at E9.5

immune system

increased inflammatory response ( J:59432 )

• extensive invasion of polymorphonuclear inflammatory granulocytes around the ectoplacental cone and the trophoectoderm

reproductive system

abnormal maternal decidual layer morphology ( J:59432 )

♀ • reduced deciduas at E9.5

nervous system

abnormal hippocampus morphology ( J:197576 )

• 20 week-old mutants (from mothers treated with an anti-C5 antibody throughout pregnancy) show a reduction in complement factor H and a decrease in tau phosphorylation in the hippocampus, both markers of Alzheimer's disease