Phenotypes Associated with This Genotype

Genotype
MGI:3696581

• Allelic Composition: Ctbp2^{Gt(ROSA61)Sor}/Ctbp2^{Gt(ROSA61)Sor}
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:77905 )

• dead by E10.5

nervous system

abnormal embryonic neuroepithelium morphology ( J:77905 )

• substantial degradation

decreased embryonic neuroepithelium thickness ( J:77905 )

• thin neuroepithelium

abnormal forebrain development ( J:77905 )

• delayed

abnormal midbrain development ( J:77905 )

• delayed

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:77905 )

• vascularization is disrupted

• however, vessels are present in the chorioallantoic plate

absent vitelline blood vessels ( J:77905 )

• yolk sac devoid of blood vessels

abnormal heart tube morphology ( J:77905 )

• heart morphogenesis is halted

• heart wall thin

• little trabeculation

distended pericardium ( J:77905 )

• dilated

embryo

abnormal placental labyrinth vasculature morphology ( J:77905 )

• vascularization is disrupted

• however, vessels are present in the chorioallantoic plate

absent vitelline blood vessels ( J:77905 )

• yolk sac devoid of blood vessels

decreased embryo size ( J:77905 )

• axial truncation

abnormal embryonic neuroepithelium morphology ( J:77905 )

• substantial degradation

decreased embryonic neuroepithelium thickness ( J:77905 )

• thin neuroepithelium

abnormal placenta development ( J:77905 )

• later steps in chorioallantoic branching are disrupted

growth/size/body

decreased embryo size ( J:77905 )

• axial truncation