Phenotypes Associated with This Genotype

Genotype
MGI:3695135

hm1

• Allelic Composition: Cxcl10^tm1Adl/Cxcl10^tm1Adl
• Genetic Background: B6.129S4-Cxcl10^tm1Adl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:120743 )

• only CCL2 levels are elevated in corneas relative to wild-type or Cxcl9-null mice after HSV-1 infection

increased susceptibility to experimental autoimmune encephalomyelitis ( J:87076 )

• higher incidence and greater severity of experimental autoimmune encephalomyelitis

CNS inflammation ( J:87076 )

• experimental autoimmune encephalomyelitis involves meningeal and brain parenchyma after 15 days

• monocytes lymphocytes and some granulocytes are involved

• increased levels of IFN-gamma, Il-2 and TGF-Beta1 in lymph nodes

increased susceptibility to Herpesvirales infection ( J:120743 )

• 7 days after infection (day 7 pi) with herpes simplex virus type I (HSV-1), homozygotes have significantly higher HSV-1 titers in the cornea compared to Cxcl9-null or wild-type mice

• virus shedding in the tear film is elevated at day 7 pi but not at early points relative to Cxcl9 homozygotes or wild-type controls

• mice usually succumb to infection between days 7 and 9 pi

nervous system

CNS inflammation ( J:87076 )

• experimental autoimmune encephalomyelitis involves meningeal and brain parenchyma after 15 days

• monocytes lymphocytes and some granulocytes are involved

• increased levels of IFN-gamma, Il-2 and TGF-Beta1 in lymph nodes