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Cxcl10tm1Adl
Targeted Allele Detail
Summary
Symbol: Cxcl10tm1Adl
Name: C-X-C motif chemokine ligand 10; targeted mutation 1, Andrew D Luster
MGI ID: MGI:2180678
Synonyms: IP-10-
Gene: Cxcl10  Location: Chr5:92494497-92496748 bp, - strand  Genetic Position: Chr5, 46.57 cM
Alliance: Cxcl10tm1Adl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75584
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-3, which encompass most of the coding region of the gene, were replaced with a PGK-neo cassette via homologous recombination. Northern and Western blot analyses of bone marrow macrophages confirmed the absence of gene expression in homozygous mutant animals. (J:75584)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cxcl10 Mutation:  14 strains or lines available
References
Original:  J:75584 Dufour JH, et al., IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol. 2002 Apr 1;168(7):3195-204
All:  63 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/21/2023
MGI 6.22
The Jackson Laboratory