Phenotypes Associated with This Genotype

Genotype
MGI:3695133

hm2

• Allelic Composition: Cxcl10^tm1Adl/Cxcl10^tm1Adl
• Genetic Background: involves: 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased splenocyte proliferation ( J:75584 )

• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA

• proliferative responses after sensitization to specific antigens is also reduced

decreased IgG2a level ( J:75584 )

• reduced levels of antigen specific IgG2a in serum when immunized with OVA

decreased susceptibility to type IV hypersensitivity reaction ( J:75584 )

• reduced contact hypersensitivity

decreased interferon-gamma secretion ( J:75584 )

• secretion of IFN-gamma reduced 60%

hematopoietic system

decreased splenocyte proliferation ( J:75584 )

• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA

• proliferative responses after sensitization to specific antigens is also reduced

decreased IgG2a level ( J:75584 )

• reduced levels of antigen specific IgG2a in serum when immunized with OVA

cellular

decreased splenocyte proliferation ( J:75584 )

• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA

• proliferative responses after sensitization to specific antigens is also reduced