Phenotypes for Spi1 Tg(Mx1-cre)1Cgn MGI:3688720 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Spi1^tm2.1Dgt/Spi1^tm2Dgt Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spi1^tm2.1Dgt mutation (0 available); any Spi1 mutation (27 available)
Spi1^tm2Dgt mutation (1 available); any Spi1 mutation (27 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal blood cell morphology/development ( J:114150 )

• 2-3 weeks after induction of cre expression with pI-pC, number of HSCs in bone marrow is decreased with loss of CMPs, GMPs and mature myeloid cells while MEPs are increased; mature granulocytes have disappeared

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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