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Phenotypes Associated with This Genotype
Genotype
MGI:3624416
Allelic
Composition		 Psen1tm1Zhe/Psen1tm1Zhe
Tg(APPSWE)2576Kha/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Zhe mutation (0 available); any Psen1 mutation (61 available)
Tg(APPSWE)2576Kha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:107251 )
• dramatically higher plaque density in brain compared to control Tg(APPSWE)2576Kahs transgenic mice
• numerous plaques could be detected in both the cortex and hippocampus at 10 month

homeostasis/metabolism
amyloid beta deposits ( J:107251 )
• dramatically higher plaque density in brain compared to control Tg(APPSWE)2576Kahs transgenic mice
• numerous plaques could be detected in both the cortex and hippocampus at 10 month

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:107251

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory