Psen1^tm1Zhe
Targeted Allele Detail

Summary

• Symbol: Psen1^tm1Zhe
• Name: presenilin 1; targeted mutation 1, Hui Zheng
• MGI ID: MGI:3623206
• Synonyms: PS1 deltaE10
• Gene: Psen1 Location: Chr12:83734926-83781869 bp, + strand Genetic Position: Chr12, 38.84 cM
• Alliance: Psen1^tm1Zhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107251
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 10, which encodes most of the hydrophilic loop, was removed from the locus via cre-mediated recombination. Western blot detected a truncated C-terminal fragment due to the deletion of the exon. (J:107251)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psen1 Mutation: 46 strains or lines available

References

• Original: J:107251 Deng Y, et al., Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. J Neurosci. 2006 Apr 5;26(14):3845-54
• All: 2 reference(s)