Phenotypes Associated with This Genotype

Genotype
MGI:3620683

• Allelic Composition: Hdc^tm1Nagy/Hdc^tm1Nagy
• Genetic Background: B6.129-Hdc^tm1Nagy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:106034 , J:105032 )

• females show impairments in spatial learning and memory in the water-maze test compared to age-matched controls (J:106034)

• male null animals show an age-dependent impaired spatial memory retention compared to age-matched controls (J:105032)

abnormal passive avoidance behavior ( J:106034 )

• female null animals show enhanced emotional memory retention in passive avoidance training compared to wild-type

decreased exploration in new environment ( J:105032 )

• male null mice spend less time exploring than control mice; 3-5 month old null mice show reduced levels of novel object recognition than aged-matched controls or older null animals and age-matched controls

abnormal spatial learning ( J:105032 )

• young male null mice show enhanced spatial learning in water-maze tests compared to age-matched controls

increased anxiety-related response ( J:106034 , J:105032 )

• 3-5 month old female null mice show more anxiety-like behavior and move less than age-matched wild-type mice assessed by time spent in the center in an open field test; 12-14 month old mice null mice show similar increased anxiety-like responses (J:106034)

• in a light-dark test, young and older female null mice move less and show more anxiety-like behavior than wild-type (as measured by increased time spent in the dark) (J:106034)

• in an elevated plus-maze, older null females move less and show less total maze-arm entries than age matched controls (J:106034)

• 3-5 month old male null mice show more anxiety-like behavior and move less than age-matched wild-type mice assessed by time spent in the center in an open field test; 12-14 month old mice null mice show increased anxiety-like responses also, but these are somewhat lower than the response of young null animals (J:105032)

• in a light-dark test, male null mice move less and show more anxiety-like behavior than wild-type (as measured by increased time spent in the dark); older mice show reduced anxiety-like behavior than young ones (J:105032)