Phenotypes Associated with This Genotype

Genotype
MGI:3620105

• Allelic Composition: Tg(Pbsn-MYC)6Key/?
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:85480 )

♂ • transition to cancer occurs in all male transgenic mice by 6-12 months of age and to invasive adenocarcinoma of the prostate after 1 year of age

increased prostate gland adenocarcinoma incidence ( J:85480 )

♂ • invasive adenocarcinoma of the prostate after 1 year of age

increased prostate intraepithelial neoplasia incidence ( J:85480 )

♂ • all male mice with this transgene develop mouse prostatic intraepithelial neoplasia (mPIN); lesions usually can be observed by 4 weeks of age

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:85480 )

♂ • transition to cancer occurs in all male transgenic mice by 6-12 months of age and to invasive adenocarcinoma of the prostate after 1 year of age

increased prostate gland adenocarcinoma incidence ( J:85480 )

♂ • invasive adenocarcinoma of the prostate after 1 year of age

increased prostate intraepithelial neoplasia incidence ( J:85480 )

♂ • all male mice with this transgene develop mouse prostatic intraepithelial neoplasia (mPIN); lesions usually can be observed by 4 weeks of age

reproductive system

increased prostate gland tumor incidence ( J:85480 )

♂ • transition to cancer occurs in all male transgenic mice by 6-12 months of age and to invasive adenocarcinoma of the prostate after 1 year of age

increased prostate gland adenocarcinoma incidence ( J:85480 )

♂ • invasive adenocarcinoma of the prostate after 1 year of age

increased prostate intraepithelial neoplasia incidence ( J:85480 )

♂ • all male mice with this transgene develop mouse prostatic intraepithelial neoplasia (mPIN); lesions usually can be observed by 4 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:85480