About   Help   FAQ
Tg(Pbsn-MYC)6Key
Transgene Detail
Summary
Symbol: Tg(Pbsn-MYC)6Key
Name: transgene insertion 6, Charles L Sawyers
MGI ID: MGI:3619445
Synonyms: Lo-Myc, PB-Myc-PAI
Transgene: Tg(Pbsn-MYC)6Key  Location: unknown  
Alliance: Tg(Pbsn-MYC)6Key page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Pbsn-MYC)6Key expresses 1 gene
 
Mutation detailsNucleotides -426 through +28 of the rat probasin gene, containing its androgen-inducible, prostate-specific promoter, were joined to a human MYC cDNA flanked by a FLAG epitope coding sequence and the polyadenylation signal from the insulin receptor gene. Immunoblot analysis with an antibody specific for human MYC demonstrates expression in prostate of mice as young as two weeks of age, which increases as the mice approach puberty at approximately 4 weeks. (J:85480)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Tumor Data
List all tumor models in MMHCdb carrying Tg(Pbsn-MYC)6Key
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:85480 Ellwood-Yen K, et al., Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell. 2003 Sep;4(3):223-38
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory