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Phenotypes Associated with This Genotype
Genotype
MGI:3614634
Allelic
Composition
Abca1tm2Jp/Abca1tm2Jp
Tg(APOA1)427Bres/?
Genetic
Background
involves: 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm2Jp mutation (1 available); any Abca1 mutation (88 available)
Tg(APOA1)427Bres mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• significantly reduced total plasma cholesterol
• significantly reduced free cholesterol
• significantly reduced levels of esterified cholesterol
• significantly reduced HDL cholesterol
• lower than in absence of transgene
• faster plasma HDL catabolism
• significantly reduced phospolipid levels
• human apoA-I not detectable in plasma

renal/urinary system
• two fold increase in HDL catabolism in the kidney

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Tangier disease DOID:1388 OMIM:205400
J:104719


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory