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Targeted Allele Detail
Symbol: Abca1tm2Jp
Name: ATP-binding cassette, sub-family A (ABC1), member 1; targeted mutation 2, John S Parks
MGI ID: MGI:3613250
Synonyms: Abca1-
Gene: Abca1  Location: Chr4:53030787-53159895 bp, - strand  Genetic Position: Chr4, 28.57 cM, cytoband A5-B3
Alliance: Abca1tm2Jp page
Germline Transmission:  Earliest citation of germline transmission: J:104719
Parent Cell Line:  ESVJ (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced exons 17-22 of the locus, which encode the first nucleotide binding domain. (J:104719)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abca1 Mutation:  61 strains or lines available
Original:  J:104719 Lee JY, et al., HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney. J Lipid Res. 2005 Oct;46(10):2233-45
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory