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Phenotypes Associated with This Genotype
Genotype
MGI:3610986
Allelic
Composition
Tbx1tm1Bld/Tbx1+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx1tm1Bld mutation (1 available); any Tbx1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at weaning there is 4.1% loss of homozygotes compared to expected numbers

cardiovascular system
• at E10.5, all heterozygotes exhibit at least one abnormal fourth pharyngeal arch artery (PAA), that is typically scored as abnormally small or absent

craniofacial
• at E10.5, all heterozygotes exhibit at least one abnormal fourth pharyngeal arch artery (PAA), that is typically scored as abnormally small or absent

embryo
• at E10.5, all heterozygotes exhibit at least one abnormal fourth pharyngeal arch artery (PAA), that is typically scored as abnormally small or absent

digestive/alimentary system

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
DiGeorge syndrome DOID:11198 OMIM:188400
J:67409


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory