Analysis Tools
mortality/aging
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• hemizygous progeny are born at less than one-third the expected Mendelian frequency, most dying by 16.5 days post coitum (16.5 dpc)
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nervous system
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• hemizygous embyros examined at 9.5 dpc often exhibit midline forebrain defects and other aspects of holoprocencephaly
• some hemizygotes that survive to birth exhibit holoprosencephalic phenotypes of varying severity
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vision/eye
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• some hemizygous embryos and liveborn pups exhibit structural eye defects
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