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Phenotypes Associated with This Genotype
Genotype
MGI:3603798
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Igbp1tm1Imku/Y
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Igbp1tm1Imku mutation (0 available); any Igbp1 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal somatic hypermutation frequency ( J:74619 )
• no somatic hypermutation takes place
decreased B cell number ( J:74619 )
• decreased B220+ cells but cells have a normal maturation phenotype
• decreased numbers involve IgM+ IgDhi
decreased follicular B cell number ( J:74619 )
• CD23+IgM+ follicular cells in the spleen were reduced as were CD40+ cells
decreased pre-B cell number ( J:74619 )
• reduced in numbers although normal numbers of pro B cells are present in bone marrow
abnormal spleen germinal center morphology ( J:74619 )
• germinal center formation is impaired
decreased B cell proliferation ( J:74619 )
• impaired proliferative responses, failure of G1/S transition
decreased immunoglobulin level ( J:74619 )
• stimulated antibody production is low
• T cell dependent antibody production more affected than T cell independent production

hematopoietic system
abnormal somatic hypermutation frequency ( J:74619 )
• no somatic hypermutation takes place
decreased B cell number ( J:74619 )
• decreased B220+ cells but cells have a normal maturation phenotype
• decreased numbers involve IgM+ IgDhi
decreased follicular B cell number ( J:74619 )
• CD23+IgM+ follicular cells in the spleen were reduced as were CD40+ cells
decreased pre-B cell number ( J:74619 )
• reduced in numbers although normal numbers of pro B cells are present in bone marrow
abnormal spleen germinal center morphology ( J:74619 )
• germinal center formation is impaired
decreased B cell proliferation ( J:74619 )
• impaired proliferative responses, failure of G1/S transition
decreased immunoglobulin level ( J:74619 )
• stimulated antibody production is low
• T cell dependent antibody production more affected than T cell independent production

cellular
decreased B cell proliferation ( J:74619 )
• impaired proliferative responses, failure of G1/S transition

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory