Phenotypes Associated with This Genotype

Genotype
MGI:3603011

• Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1Hon; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small thymus ( J:99747 )

• 1 and 3 months after poly(I)-poly(C) injection, thymus size is reduced

decreased thymocyte number ( J:99747 )

• 1 month after poly(I)-poly(C) injection, the number of thymocytes is reduced and by 3 months the number of thymocytes is reduced to 1/8 that in control mice

abnormal lymphopoiesis ( J:99747 )

• 1 and 3 months after poly(I)-poly(C) injection, in the thymus and bone marrow lymphocyte progenitors induce B cell development at the expense of T cell development; however myeloid and B cell lineage development in the bone marrow is normal

abnormal B cell differentiation ( J:99747 )

• after poly(I)-poly(C) injection, B cell development is impaired in the spleen but not in the bone marrow

increased double-negative T cell number ( J:99747 )

• 1 and 3 months after poly(I)-poly(C) injection, a progressive increase in the number of double negative cells is seen in the thymus; however many of these cells are B cells

decreased double-positive T cell number ( J:99747 )

• 1 and 3 months after poly(I)-poly(C) injection, a progressive decrease in the number of double positive cells is seen in the thymus

arrested T cell differentiation ( J:99747 , J:125869 )

• 1 and 3 months after poly(I)-poly(C) injection, T cell development is arrested at the CD44+CD25- pro-T cell or earlier stage (J:99747)

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, mice manifest a block in T cell development in the thymus (J:125869)

increased plasmacytoid dendritic cell number ( J:125869 )

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, fraction of PDCs is elevated in the spleen

decreased dendritic cell number ( J:125869 )

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, proportion of conventional Cd11c^high MHC class II⁺ dendritic cells is reduced 2.5 fold; decrease in the fraction of Cd11b⁺ dendritic cells corresponding to the CD8^- subset is consistently observed

decreased marginal zone B cell number ( J:76240 , J:99747 )

• one month after IFN-induced deletion, mutants show a gradual deletion of marginal zone B cells, from 10% to 3% of splenic B cells (J:76240)

• after poly(I)-poly(C) injection, marginal zone B cells are drastically reduced in spleen (J:99747)

increased B cell number ( J:99747 , J:125869 )

• 1 and 3 months after poly(I)-poly(C) injection, a progressive increase in the number of B cells is seen in the thymus (J:99747)

• after poly(I)-poly(C) injection, pro-B and pre-B cell numbers are increased in the thymus (J:99747)

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, increased B cell development in the thymus is observed (J:125869)

increased follicular B cell number ( J:99747 )

• after poly(I)-poly(C) injection, follicular B cells are slightly increased in spleen

decreased single-positive T cell number ( J:99747 )

• 1 and 3 months after poly(I)-poly(C) injection, a progressive decrease in the number of single positive cells is seen in the thymus

increased macrophage cell number ( J:125869 )

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, fraction of Cd11b⁺ Cd11c^- monocytes/macrophages is elevated in the spleen

increased monocyte cell number ( J:125869 )

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, fraction of Cd11b⁺ Cd11c^- monocytes/macrophages is elevated in the spleen

decreased follicular dendritic cell number ( J:125869 )

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, there is decreased splenic dendritic cell content

hematopoietic system

small thymus ( J:99747 )

• 1 and 3 months after poly(I)-poly(C) injection, thymus size is reduced

decreased thymocyte number ( J:99747 )

• 1 month after poly(I)-poly(C) injection, the number of thymocytes is reduced and by 3 months the number of thymocytes is reduced to 1/8 that in control mice

abnormal lymphopoiesis ( J:99747 )

• 1 and 3 months after poly(I)-poly(C) injection, in the thymus and bone marrow lymphocyte progenitors induce B cell development at the expense of T cell development; however myeloid and B cell lineage development in the bone marrow is normal

abnormal B cell differentiation ( J:99747 )

• after poly(I)-poly(C) injection, B cell development is impaired in the spleen but not in the bone marrow

increased double-negative T cell number ( J:99747 )

• 1 and 3 months after poly(I)-poly(C) injection, a progressive increase in the number of double negative cells is seen in the thymus; however many of these cells are B cells

decreased double-positive T cell number ( J:99747 )

• 1 and 3 months after poly(I)-poly(C) injection, a progressive decrease in the number of double positive cells is seen in the thymus

arrested T cell differentiation ( J:99747 , J:125869 )

• 1 and 3 months after poly(I)-poly(C) injection, T cell development is arrested at the CD44+CD25- pro-T cell or earlier stage (J:99747)

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, mice manifest a block in T cell development in the thymus (J:125869)

increased plasmacytoid dendritic cell number ( J:125869 )

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, fraction of PDCs is elevated in the spleen

decreased dendritic cell number ( J:125869 )

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, proportion of conventional Cd11c^high MHC class II⁺ dendritic cells is reduced 2.5 fold; decrease in the fraction of Cd11b⁺ dendritic cells corresponding to the CD8^- subset is consistently observed

decreased marginal zone B cell number ( J:76240 , J:99747 )

• one month after IFN-induced deletion, mutants show a gradual deletion of marginal zone B cells, from 10% to 3% of splenic B cells (J:76240)

• after poly(I)-poly(C) injection, marginal zone B cells are drastically reduced in spleen (J:99747)

increased B cell number ( J:99747 , J:125869 )

• 1 and 3 months after poly(I)-poly(C) injection, a progressive increase in the number of B cells is seen in the thymus (J:99747)

• after poly(I)-poly(C) injection, pro-B and pre-B cell numbers are increased in the thymus (J:99747)

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, increased B cell development in the thymus is observed (J:125869)

increased follicular B cell number ( J:99747 )

• after poly(I)-poly(C) injection, follicular B cells are slightly increased in spleen

decreased single-positive T cell number ( J:99747 )

• 1 and 3 months after poly(I)-poly(C) injection, a progressive decrease in the number of single positive cells is seen in the thymus

increased macrophage cell number ( J:125869 )

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, fraction of Cd11b⁺ Cd11c^- monocytes/macrophages is elevated in the spleen

increased monocyte cell number ( J:125869 )

• 3 weeks after induction of cre expression by poly(I):poly(C) treatment, fraction of Cd11b⁺ Cd11c^- monocytes/macrophages is elevated in the spleen

endocrine/exocrine glands

small thymus ( J:99747 )

• 1 and 3 months after poly(I)-poly(C) injection, thymus size is reduced

decreased thymocyte number ( J:99747 )

• 1 month after poly(I)-poly(C) injection, the number of thymocytes is reduced and by 3 months the number of thymocytes is reduced to 1/8 that in control mice