About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3586914
Allelic
Composition
Tbx1tm1Pa/Tbx1+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx1tm1Pa mutation (2 available); any Tbx1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• Background Sensitivity: the incidence of this phenotype is increased on an inbred 129 background compared to mixed 129 and C57BL/6 or 129 and Swiss Webster backgrounds
• at E11.5, the fourth aortic arch arteries are either absent or reduced in thickness in 45% of heterozygotes compared to 7% of wild-type embryos

craniofacial
• Background Sensitivity: the incidence of this phenotype is increased on an inbred 129 background compared to mixed 129 and C57BL/6 or 129 and Swiss Webster backgrounds
• at E11.5, the fourth aortic arch arteries are either absent or reduced in thickness in 45% of heterozygotes compared to 7% of wild-type embryos

embryo
• Background Sensitivity: the incidence of this phenotype is increased on an inbred 129 background compared to mixed 129 and C57BL/6 or 129 and Swiss Webster backgrounds
• at E11.5, the fourth aortic arch arteries are either absent or reduced in thickness in 45% of heterozygotes compared to 7% of wild-type embryos

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
DiGeorge syndrome DOID:11198 OMIM:188400
J:70730


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
06/12/2024
MGI 6.13
The Jackson Laboratory