Phenotypes Associated with This Genotype

Genotype
MGI:3580325

• Allelic Composition: Map3k2^tm1Bisu/Map3k2^tm1Bisu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell activation ( J:78072 )

• significant increase of apoptotic thymocytes in antibody stimulated mice

• increased DNA fragmentation in the thymus

increased T cell proliferation ( J:78072 )

• very vigorous activation and proliferation response to antibody stimulation

abnormal cytokine secretion ( J:78072 )

• more Il-2 and Ifn-gamma but less Il-4 produced by T cells

hematopoietic system

abnormal T cell activation ( J:78072 )

• significant increase of apoptotic thymocytes in antibody stimulated mice

• increased DNA fragmentation in the thymus

increased T cell proliferation ( J:78072 )

• very vigorous activation and proliferation response to antibody stimulation

cellular

increased T cell proliferation ( J:78072 )

• very vigorous activation and proliferation response to antibody stimulation