Map3k2^tm1Bisu
Targeted Allele Detail

Summary

• Symbol: Map3k2^tm1Bisu
• Name: mitogen-activated protein kinase kinase kinase 2; targeted mutation 1, Bing Su
• MGI ID: MGI:2183907
• Synonyms: Mekk2-
• Gene: Map3k2 Location: Chr18:32296142-32369804 bp, + strand Genetic Position: Chr18, 17.95 cM, cytoband B3
• Alliance: Map3k2^tm1Bisu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78072
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding 192 amino acids of the catalytic domain was replaced with a cassette containing IRES-lacZ and neo genes. The absence of truncated protein in mutant mice was determined by Western blot analysis using antibodies directed against the amino terminal and the catalytic domains. Staining identified expression of beta-galactosidase. (J:78072)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k2 Mutation: 42 strains or lines available

References

• Original: J:78072 Guo Z, et al., Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Mol Cell Biol. 2002 Aug;22(16):5761-8
• All: 9 reference(s)