Phenotypes Associated with This Genotype

Genotype
MGI:3575580

• Allelic Composition: Apc^Min/Apc⁺; Recql4^tm1Glu/Recql4^tm1Glu
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor growth/size ( J:97101 )

• the average maximal diameter of macroadenomas was larger than in double heterozygous controls

increased adenoma incidence ( J:97101 )

• at 120 days of age, exhibited a 2-fold increase in the multiplicity of macroadenomas along the entire GI tract compared to double heterozygous mutant controls, however no difference in the mean or maximal lifespan compared to controls

increased colon adenoma incidence ( J:97101 )

• mutants always developed tumors in the large intestine, a site that is inconsistently affected in double heterozygous controls

digestive/alimentary system

increased colon adenoma incidence ( J:97101 )

• mutants always developed tumors in the large intestine, a site that is inconsistently affected in double heterozygous controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rothmund-Thomson syndrome		DOID:2732	OMIM:268400	J:97101