Phenotypes Associated with This Genotype

Genotype
MGI:3575442

• Allelic Composition: Sema4a^tm1Kik/Sema4a^tm1Kik
• Genetic Background: either: B6.Cg-Sema4a^tm1Kik or C.Cg-Sema4a^tm1Kik

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:97027 )

• T helper 1 cells differentiated poorly in an in vitro assay

abnormal CD4-positive, alpha-beta T cell physiology ( J:97027 )

• in vivo antigen-specific T cell priming and antibody responses against T cell-dependent antigens are impaired

immune system

abnormal T-helper 1 cell differentiation ( J:97027 )

• T helper 1 cells differentiated poorly in an in vitro assay

abnormal CD4-positive, alpha-beta T cell physiology ( J:97027 )

• in vivo antigen-specific T cell priming and antibody responses against T cell-dependent antigens are impaired

abnormal dendritic cell antigen presentation ( J:97027 )

• dendritic cells from mutant poorly stimulated allogenic T cells

decreased susceptibility to type IV hypersensitivity reaction ( J:97027 )

• delayed type hypersensitivity reactions are impaired

abnormal cytokine secretion ( J:97027 )

• production of IFNG by Th1-conditioned cells is reduced

• antigen-induced IL-4 production by CD4+ T cells is increased but IFNG production is decreased