Sema4a^tm1Kik
Targeted Allele Detail

Summary

• Symbol: Sema4a^tm1Kik
• Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; targeted mutation 1, Hutoshi Kikutani
• MGI ID: MGI:3575087
• Gene: Sema4a Location: Chr3:88343266-88368489 bp, - strand Genetic Position: Chr3, 38.83 cM
• Alliance: Sema4a^tm1Kik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97027
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 1.8-kb of genomic sequence containing the first exon with the initiation codon was replaced with a neo cassette. RT-PCR analysis of total RNA from the spleen and cell surface staining of dendritic cells (DC) confirmed the lack of expression. (J:97027)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema4a Mutation: 39 strains or lines available

References

• Original: J:97027 Kumanogoh A, et al., Nonredundant Roles of Sema4A in the Immune System: Defective T Cell Priming and Th1/Th2 Regulation in Sema4A-Deficient Mice. Immunity. 2005 Mar;22(3):305-16
• All: 10 reference(s)