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Phenotypes Associated with This Genotype
Genotype
MGI:3574619
hm1
Allelic
Composition		 Dcntm1Ioz/Dcntm1Ioz
Genetic
Background		 C.129(Cg)-Dcntm1Ioz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcntm1Ioz mutation (0 available); any Dcn mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:92428 )
• chronically infected homozygotes lack a protective niche for Borrelia burgdorferi in joints and skin, resulting in similar spirochete burdens in joints, skin, heart and bladder; spirochete burden remains unaffected during early infection
• in infected joints, protection of B. burgdorferi against immune clearance appears to be specific for dbpA-expressing spirochetes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory