Analysis Tools
mortality/aging
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• these mutants survive longer than double homozygotes with a 50% mean survival rate of ~6 months, similar to that observed in Trp53tm1Brd mice; surprisingly, no increased incidence of infections is observed
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neoplasm
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• similar to double homozygotes, these mutants are predisposed to an accelerated mortality due to increased tumorigenesis, with no differences between male and female occurrence
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• the majority of tumors are high-grade lymphomas arising from the transformation of immature thymocytes
• tumor cells are highly invasive and infiltrate the soft tissues of mediastinum, the salivary glands, the periaortic spaces, the pericardium, and the bronchial wall
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respiratory system
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• mutants with thymic lymphomas die of pericardial compression or respiratory distress
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endocrine/exocrine glands
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• the majority of tumors are high-grade lymphomas arising from the transformation of immature thymocytes
• tumor cells are highly invasive and infiltrate the soft tissues of mediastinum, the salivary glands, the periaortic spaces, the pericardium, and the bronchial wall
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immune system
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• the majority of tumors are high-grade lymphomas arising from the transformation of immature thymocytes
• tumor cells are highly invasive and infiltrate the soft tissues of mediastinum, the salivary glands, the periaortic spaces, the pericardium, and the bronchial wall
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hematopoietic system
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• the majority of tumors are high-grade lymphomas arising from the transformation of immature thymocytes
• tumor cells are highly invasive and infiltrate the soft tissues of mediastinum, the salivary glands, the periaortic spaces, the pericardium, and the bronchial wall
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