Phenotypes Associated with This Genotype

Genotype
MGI:3036843

cx4

• Allelic Composition: Gipr^tm1Thor/Gipr^tm1Thor; Glp1r^tm1Ddr/Glp1r^tm1Ddr
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas secretion ( J:88159 )

• blunted first phase of insulin secretion

• no decrease in second phase of insulin secretion

• beta-cell autonomous defect in stimulated insulin secretion

homeostasis/metabolism

increased circulating glucose level ( J:88159 )

• observed in both males and females relative to wild-type controls following oral glucose consumption

• observed in female mice, but not male mice, following intraperitoneal glucose injection

decreased circulating insulin level ( J:88159 )

• reduced insulin response to oral glucose consumption observed in both males and females relative to wild-type controls as well as to single knockout mice

• absence of first phase insulin secretion

impaired glucose tolerance ( J:88159 )

• observed in both male and female mice, following oral glucose consumption, however females showed a greater impairment than males

• observed in female mice, but not male mice, after intraperitoneal glucose injection

• greater intolerance relative to single knockout mice

• normal insulin sensitivity indicated by euglycemic clamp