Glp1r^tm1Ddr
Targeted Allele Detail

Summary

• Symbol: Glp1r^tm1Ddr
• Name: glucagon-like peptide 1 receptor; targeted mutation 1, D J Drucker
• MGI ID: MGI:2150310
• Synonyms: GLP1Rc KO, GLP-1R KO
• Gene: Glp1r Location: Chr17:31120841-31155484 bp, + strand Genetic Position: Chr17, 15.8 cM
• Alliance: Glp1r^tm1Ddr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36918
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced two exons of the gene, which encode the first and third transmembrane domains and intervening peptide sequence. Northern blots and RT-PCR showed no detectable Glpr1 mRNA in pancreas, lung, or hypothalamus of homozygous mutant mice. (J:36918)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glp1r Mutation: 49 strains or lines available

References

• Original: J:36918 Scrocchi LA, et al., Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med. 1996 Nov;2(11):1254-8
• All: 115 reference(s)