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Allele Symbol Allele Name Allele ID |
Glp1rtm1Ddr targeted mutation 1, D J Drucker MGI:2150310 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• during glucose tolerance test
(J:36918)
• after gavage of a standard liquid diet
(J:206563)
• however, glucose levels after vertical sleeve gastrectomy are normal
(J:206563)
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• during glucose tolerance test
(J:36918)
• at baseline or after gavage of a standard liquid diet after vertical sleeve gastrectomy and in sham operated mice
(J:206563)
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• mice exhibit normal weight change rate following vertical sleeve gastrectomy
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• after vertical sleeve gastrectomy and in sham operated mice
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• after vertical sleeve gastrectomy and in sham operated mice
• however, mice exhibit normal weight change rate following vertical sleeve gastrectomy
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• after exendin-4 treatment, mice fail to exhibit a hypophagic response unlike wild-type mice
• mice exhibit unchanged protein intake after vertical sleeve gastrectomy unlike wild-type mice
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• 28 to 31 days after vertical sleeve gastrectomy and in sham operated mice
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• after vertical sleeve gastrectomy and in sham operated mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• blunted first phase of insulin secretion
• blunted second phase of insulin secretion
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• in response to oral glucose consumption observed in both males and females relative to wild-type controls
• observed in female mice, but not male mice, following intraperitoneal glucose injection
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• reduced insulin response to oral glucose consumption observed in both males and females relative to wild-type controls
• following intraperitoneal glucose injection, the first phase insulin secretion was absent
• insulin levels remained reduced 30 minutes later
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• observed in both male and female mice after oral glucose consumption
• observed in female mice, but not male mice, after intraperitoneal glucose injection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• blunted first phase of insulin secretion
• no decrease in second phase of insulin secretion
• beta-cell autonomous defect in stimulated insulin secretion
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• observed in both males and females relative to wild-type controls following oral glucose consumption
• observed in female mice, but not male mice, following intraperitoneal glucose injection
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• reduced insulin response to oral glucose consumption observed in both males and females relative to wild-type controls as well as to single knockout mice
• absence of first phase insulin secretion
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• observed in both male and female mice, following oral glucose consumption, however females showed a greater impairment than males
• observed in female mice, but not male mice, after intraperitoneal glucose injection
• greater intolerance relative to single knockout mice
• normal insulin sensitivity indicated by euglycemic clamp
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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