Phenotypes Associated with This Genotype

Genotype
MGI:2684657

• Allelic Composition: Psen1^tm1Vln/Psen1^tm1Vln; Tg(Thy1-cre)1Vln/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:87229 )

N • mice do not display any behavioral or cognitive deficits

nervous system

nervous system phenotype ( J:87229 )

N • brains of 6 month-old mice do not show any morphological abnormalities like cerebral hemorrhages, cavities or tumors; no defects are observed up to 2 years of age

amyloid beta deposits ( J:87229 )

• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains

abnormal long-term potentiation ( J:87229 )

• initial phase of the slope of fEPSP is lower (168% vs 221% in controls) 15 minutes after tetanic stimulation; slope of fEPSP progressively increases to approach control levels 2 hours following stimulation

homeostasis/metabolism

amyloid beta deposits ( J:87229 )

• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:87229
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:87229