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Phenotypes Associated with This Genotype
Genotype
MGI:2680727
Allelic
Composition
Il4ratm1Tch/Il4ratm1Tch
Genetic
Background
involves: 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Tch mutation (1 available); any Il4ra mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• impaired Il-4 induced CD4+ T cell proliferation
• decreased persistence of Th2 cells as indicated by Il-4, Il-5, and Il-13 production
• Th2 differentiation not impaired however
• levels are substantially higher than normal
• IgG1 and IgG2 levels are higher than normal in response to OVA stimulation
• airway hyperresponsiveness to methacholine
• eosinophilic infiltration
• goblet cell hyperplasia

respiratory system
• airway hyperresponsiveness to methacholine
• eosinophilic infiltration
• goblet cell hyperplasia
• with methacholine challenge

hematopoietic system
• impaired Il-4 induced CD4+ T cell proliferation
• decreased persistence of Th2 cells as indicated by Il-4, Il-5, and Il-13 production
• Th2 differentiation not impaired however
• levels are substantially higher than normal
• IgG1 and IgG2 levels are higher than normal in response to OVA stimulation

cellular
• impaired Il-4 induced CD4+ T cell proliferation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
asthma DOID:2841 OMIM:600807
J:86215


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory