Phenotypes Associated with This Genotype

Genotype
MGI:2667771

• Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:140483 )

• mice survive infection with M. tuberculosis for the period of observation (day 50), whereas Ifng-null animals all succumb rapidly to infection

• neutralization of Ifng in infected mice abolishes the resistance to infection displayed by untreated mice

digestive/alimentary system

colitis ( J:116136 )

• in this animal model of colitis, less severe pathological injury is observed in mice receiving Tg(CD2-Caecam1*4L)1Rsb T cell transfer

immune system

colitis ( J:116136 )

• in this animal model of colitis, less severe pathological injury is observed in mice receiving Tg(CD2-Caecam1*4L)1Rsb T cell transfer

decreased thymocyte number ( J:114561 )

• thymocyte number is reduced to 1-3 x 10⁶ cells compared to 200-300 x 10⁶ cells in wild-type mice

abnormal T-helper 1 physiology ( J:116136 )

• colonic lamina propria lymphocytes (LPL) produce less Ifng and IL-2 in recipients of Tg(CD2-Caecam1*4L)1Rsb T cells

abnormal macrophage physiology ( J:140483 )

• in anti-Ifng treated mice, upregulation of Nos2 production by macrophages is abolished after M. tuberculosis infection relative to untreated Rag2-null mice wherease YM-1 and L-arginase 1 expression are elevated 60- and 3000-fold compared to untreated mutants

abnormal chemokine secretion ( J:140483 )

• chemokines KC and MIP-2 are increased in NK cells in infected lungs of anti-Ifng treated mice

abnormal interferon secretion ( J:140483 )

• incubation of Rag2-null splenocytes with mycobacteria (M. tuberculosis) induces high levels of interferon gamma; this induction is increased at higher multiplicities of infection (MOI)

lung inflammation ( J:140483 )

• at 28 days p.i., lungs display a few small foci with limited mononuclear infiltration

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:140483 )

• mice survive infection with M. tuberculosis for the period of observation (day 50), whereas Ifng-null animals all succumb rapidly to infection

• neutralization of Ifng in infected mice abolishes the resistance to infection displayed by untreated mice

increased susceptibility to bacterial infection ( J:140483 )

• in lungs and spleens of M. tuberculosis-infected mice at 28 days post-infection (p.i.), bacterial loads are higher than in infected wild-type mice

• neutralization of Ifng in infected mice results in 0.5-1.0 log higher bacterial burdens in lungs and spleens than in untreated Rag2-null mice

abnormal response to transplant ( J:116136 )

• in a mouse model of colitis, recipients of Tg(CD2-Caecam1*4L)1Rsb splenic T cells display less severe wasting than recipients of wild-type splenic T cells`

• this is associated with less severe macro- and microscopic colitis

hematopoietic system

decreased thymocyte number ( J:114561 )

• thymocyte number is reduced to 1-3 x 10⁶ cells compared to 200-300 x 10⁶ cells in wild-type mice

abnormal T-helper 1 physiology ( J:116136 )

• colonic lamina propria lymphocytes (LPL) produce less Ifng and IL-2 in recipients of Tg(CD2-Caecam1*4L)1Rsb T cells

abnormal macrophage physiology ( J:140483 )

• in anti-Ifng treated mice, upregulation of Nos2 production by macrophages is abolished after M. tuberculosis infection relative to untreated Rag2-null mice wherease YM-1 and L-arginase 1 expression are elevated 60- and 3000-fold compared to untreated mutants

respiratory system

lung inflammation ( J:140483 )

• at 28 days p.i., lungs display a few small foci with limited mononuclear infiltration

endocrine/exocrine glands

decreased thymocyte number ( J:114561 )

• thymocyte number is reduced to 1-3 x 10⁶ cells compared to 200-300 x 10⁶ cells in wild-type mice