Phenotypes Associated with This Genotype

Genotype
MGI:2451231

• Allelic Composition: Fbn2^fp/Fbn2^fp
• Genetic Background: C3Fe(B6)-Fbn2^fp/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Limb clasping, reduced grip strength, and syndactyly in Fbn2^mz/Fbn2^mz, Fbn2^fp/Fbn2^fp and Fbn2^mz/Fbn2^fp mice

behavior/neurological

limb grasping ( J:157998 )

decreased grip strength ( J:157998 )

muscle

muscle weakness ( J:157998 )

limbs/digits/tail

syndactyly ( J:13514 , J:157998 )

• variable penetrance, usually of digits 2 and 3 or 3 and 4, more rarely 2, 3 and 4; more frequent incidence in hindpaws than forepaws (J:13514)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	distal arthrogryposis	DOID:0050646	OMIM:PS108120	J:68881