About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2386740
Allelic
Composition		 Abcb1atm1Bor/Abcb1atm1Bor
Npc1m1N/Npc1m1N
Genetic
Background		 involves: 129/Ola * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1atm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Npc1m1N mutation (3 available); any Npc1 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal motor capabilities/coordination/movement ( J:76395 )
• neurological symptoms apparent and progressive, beginning at ~ day 50 of life
abnormal maternal nurturing ( J:76395 )
• failed to care for pups

homeostasis/metabolism
increased liver cholesterol level ( J:76395 )
• cholesterol accumulation in liver

reproductive system
reproductive system phenotype ( J:76395 )
N
• mice were fertile

liver/biliary system
increased liver cholesterol level ( J:76395 )
• cholesterol accumulation in liver

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Niemann-Pick disease DOID:14504 J:76395

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory