Phenotypes Associated with This Genotype

Genotype
MGI:2176814

• Allelic Composition: Grik2^tm1Sfh/Grik2^tm1Sfh
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:46932 )

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:46932 )

• almost all homozygotes are protected against kainate-induced seizures after intraperitoneal injection of 20 mg kainate/kg

• however; performance in other behavioral tests including rotarod, Morris water maze, and sensorimotor tests is similar to wild-type

abnormal glutamate-mediated receptor currents ( J:46932 )

• kainate fails to activate inward currents in CA3 neurons of the hippocampus at concentrations up to 3uM

abnormal long-term potentiation ( J:91763 )

• LTP induced significantly less than controls in hippocampal mossy fibers

reduced long-term potentiation ( J:98109 )

• theta burst stimulation fails to produce long term potentiation in the lateral amygdala

decreased paired-pulse facilitation ( J:91763 )

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:46932 )

• almost all homozygotes are protected against kainate-induced seizures after intraperitoneal injection of 20 mg kainate/kg

• however; performance in other behavioral tests including rotarod, Morris water maze, and sensorimotor tests is similar to wild-type

abnormal contextual conditioning behavior ( J:98109 )

• reduced contextual fear memory

abnormal cued conditioning behavior ( J:98109 )

• reduced auditory fear memory

decreased fear-related response ( J:98109 )

• reduced contextual and auditory fear memory