Phenotypes Associated with This Genotype

Genotype
MGI:2175714

• Allelic Composition: B2m^tm1Jae/B2m^tm1Jae
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:80910 , J:744 )

• 100-150-fold reduction in T-cell antigen receptor alpha-beta⁺ CD4^-CD8⁺ T cells in adult thymus and spleen, however levels of gamma-delta T cells is normal (J:80910)

• decreased proportion of CD8⁺ alpha-beta⁺ T cells (J:744)

increased gamma-delta T cell number ( J:744 )

• frequency of gamma-delta⁺ T cells was considerably higher in the thymus (11% vs. 6.5% of CD4^-CD8^- thymocytes), however development and functional competence of gamma-delta⁺ T cells was normal

increased gamma-delta intraepithelial T cell number ( J:744 )

• increased frequency of gamma-delta⁺ T cells in the intestinal epithelium

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:80910 )

• spleen cells did not contain cytotoxic T lymphocyte precursors

abnormal cytotoxic T cell physiology ( J:80910 )

• spleen cells fail to generate allo-specific cytotoxic T lympocyte response when stimulated with BALB/c (H-2^d) spleen cells

immune system

decreased CD8-positive, alpha-beta T cell number ( J:80910 , J:744 )

• 100-150-fold reduction in T-cell antigen receptor alpha-beta⁺ CD4^-CD8⁺ T cells in adult thymus and spleen, however levels of gamma-delta T cells is normal (J:80910)

• decreased proportion of CD8⁺ alpha-beta⁺ T cells (J:744)

increased gamma-delta T cell number ( J:744 )

• frequency of gamma-delta⁺ T cells was considerably higher in the thymus (11% vs. 6.5% of CD4^-CD8^- thymocytes), however development and functional competence of gamma-delta⁺ T cells was normal

increased gamma-delta intraepithelial T cell number ( J:744 )

• increased frequency of gamma-delta⁺ T cells in the intestinal epithelium

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:80910 )

• spleen cells did not contain cytotoxic T lymphocyte precursors

abnormal cytotoxic T cell physiology ( J:80910 )

• spleen cells fail to generate allo-specific cytotoxic T lympocyte response when stimulated with BALB/c (H-2^d) spleen cells