Analysis Tools
mortality/aging
|
• reduced survival 8 days after 30 minutes of experimentally induced kidney eschemia relative to controls
|
cardiovascular system
| N |
• blood pressure and heart rate are normal
|
|
• blood pressure drops less in response to LPS injection than it does in controls
|
homeostasis/metabolism
| N |
• after injection of platelet-activating factor (PAF), >90% mortality occurs within 30 minutes, similar to wild-type controls
• pretreatment with wortmannin before PAF treatment confers 100% protection to mutants and wild-type
|
|
• higher plasma creatinine levels 24 hours after experimentally induced kidney eschemia than in controls
|
|
• elevation in plasma AVP due to LPS injection persists longer than controls, still significantly elevated after 6 hours whereas levels more moderately elevated in controls aftr 4 hours.
|
|
• plasma leptin concentrations are significantly reduced
|
|
• elevated tissue myeloperoxidase levels relative to controls 9 days after kidney eschemia
|
|
• hyperglycemic in the first 30 minutes of a glucose tolerance test
• return to fasting glucose levels by 90 minutes when controls are still hyperglycemic
|
immune system
| N |
• growth of Mycobacterium leprae unaffected
(J:64036)
• homozygotes are indistinguishable from wild-type in appearance, histology, growth rate, reproduction, and in mortality in an LPS-induced model of septic shock
(J:29677)
|
|
• increased numbers of both CD4+ and CD8+ cells in inguinal lymph nodes
|
|
• increased cellularity of inguinal lymph nodes
|
|
• primary immune responses are unaffected
|
|
• increased T-cell proliferative response to protein antigens
• "clonal burst size" is unchanged
|
|
• greatly increased granulomatous inflammation when infected with Mycobacterium leprae
• resembles borderline tuberculoid lesions of leprosy
|
|
• intracellular growth of Mycobacterium tuberculosis and Francisella tularensis is increased but to highly variable extent
|
neoplasm
|
• increased rate of growth of ascites tumor cells
• no apoptosis in ascites tumor cells 2 weeks after innoculation
• growth of solid tumors from ascites tumor cells is prevented
|
adipose tissue
|
• reduced amounts of epididymal white adipose tissue
|
reproductive system
 |
• significantly increased diameter and volume
|
|
|
• 31% increase
|
|
|
• numbers of pachytene spermatocytes and round spermatids are increased
• decreased apoptosis of pachytene, early round spermatids at stages I-IV, and diplotene dividing spermatocytes at stages XI-XII
• reduced heat induced apoptosis
|
|
|
• 65.5% increase in sperm content
|
|
• significantly higher numbers of 2-celled embryos produced when homozygotes are intercrossed
• blastocyst formation is similar to controls
• fertilization rate of mutant sperm and normal ova is significantly higher than controls
• fertilization rate of mutant ova and normal sperm is much higher than controls
|
endocrine/exocrine glands
|
|
• significantly increased diameter and volume
|
|
|
• 31% increase
|
hematopoietic system
|
• increased T-cell proliferative response to protein antigens
• "clonal burst size" is unchanged
|
|
• increased numbers of both CD4+ and CD8+ cells in inguinal lymph nodes
|
growth/size/body
|
• experience greater weight gain on a high fat diet
|
behavior/neurological
|
• consume 1.6 times as much food as controls on a high fat diet
|
integument
|
• greatly increased granulomatous inflammation when infected with Mycobacterium leprae
• resembles borderline tuberculoid lesions of leprosy
|
cellular
|
|
• numbers of pachytene spermatocytes and round spermatids are increased
• decreased apoptosis of pachytene, early round spermatids at stages I-IV, and diplotene dividing spermatocytes at stages XI-XII
• reduced heat induced apoptosis
|
|
• increased T-cell proliferative response to protein antigens
• "clonal burst size" is unchanged
|
