Phenotypes associated with this allele

• Allele Symbol: B3gnt8^em1Yoxi
• Allele Name: endonuclease-mediated mutation 1, Yongtao Xiao
• Allele ID: MGI:8473437
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	B3gnt8^em1Yoxi/B3gnt8^em1Yoxi	C57BL/6J-B3gnt8^em1Yoxi	MGI:8473459

Genotype
MGI:8473459

hm1

• Allelic Composition: B3gnt8^em1Yoxi/B3gnt8^em1Yoxi
• Genetic Background: C57BL/6J-B3gnt8^em1Yoxi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal goblet cell physiology ( J:378156 )

• abnormal mucus secretion compared with wild-type mice

abnormal feces composition ( J:378156 )

• decreased fecal pH

• in the feces, mice exhibited a higher abundance of operational taxonomic units in the genera Pseudomonas, Fimbriimonadaceae, OLB12, and a reduction in Escherichia-Shigella and Candidatus-Kuenenia compared with wild-type mice

abnormal intestine morphology ( J:378156 )

• fragile intestinal tissue

• damaged intercellular junctions among intestinal epithelial cells with irregular distribution of microvilli

decreased intestine goblet cell number ( J:378156 )

• in the small intestines and colons

decreased colon goblet cell number ( J:378156 )

decreased Paneth cell number ( J:378156 )

• with fewer and smaller granules

decreased colon length ( J:378156 )

abnormal gut flora balance ( J:378156 )

• in the feces, mice exhibited a higher abundance of operational taxonomic units in the genera Pseudomonas, Fimbriimonadaceae, OLB12, and a reduction in Escherichia-Shigella and Candidatus-Kuenenia compared with wild-type mice

abnormal Paneth cell physiology ( J:378156 )

• impaired autophagy

increased susceptibility to induced colitis ( J:378156 )

• DSS-treated mice exhibit increased inflammation compared with similarly treated wild-type mice

growth/size/body

postnatal growth retardation ( J:378156 )

immune system

increased inflammatory response ( J:378156 )

• inflammation in the liver, lung, brain, kidney, and pancreas

increased susceptibility to induced colitis ( J:378156 )

• DSS-treated mice exhibit increased inflammation compared with similarly treated wild-type mice

pancreas inflammation ( J:378156 )

brain inflammation ( J:378156 )

liver inflammation ( J:378156 )

kidney inflammation ( J:378156 )

lung inflammation ( J:378156 )

renal/urinary system

kidney inflammation ( J:378156 )

nervous system

brain inflammation ( J:378156 )

liver/biliary system

liver inflammation ( J:378156 )

respiratory system

lung inflammation ( J:378156 )

integument

disheveled coat ( J:378156 )

• unkempt fur

endocrine/exocrine glands

decreased colon goblet cell number ( J:378156 )

decreased Paneth cell number ( J:378156 )

• with fewer and smaller granules

pancreas inflammation ( J:378156 )

cellular

decreased intestine goblet cell number ( J:378156 )

• in the small intestines and colons

decreased colon goblet cell number ( J:378156 )

abnormal intestinal goblet cell physiology ( J:378156 )

• abnormal mucus secretion compared with wild-type mice