B3gnt8^em1Yoxi
Endonuclease-mediated Allele Detail

Summary

• Symbol: B3gnt8^em1Yoxi
• Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8; endonuclease-mediated mutation 1, Yongtao Xiao
• MGI ID: MGI:8473437
• Synonyms: B3gnt8^{deltaexons1-2}
• Gene: B3gnt8 Location: Chr7:25327025-25328917 bp, + strand Genetic Position: Chr7, 13.94 cM
• Alliance: B3gnt8^em1Yoxi page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  CRISPR/cas-medaited targeting deleted 348 bp encoding exons 1 and 2 (ENSMUST00000076034.7). Western blot analysis confirmed the absence of protein expression in the small intestine. (J:378156)

• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any B3gnt8 Mutation: 13 strains or lines available

References

• Original: J:378156 Mao H, et al., B3GNT8-mediated glycosylation maintains intestinal homeostasis and protects against colitis. J Biol Chem. 2025 Dec 10;302(2):111014
• All: 1 reference(s)