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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb
endonuclease-mediated mutation 4.1, Robert W Burgess
MGI:8433685
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb/Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb involves: C57BL/6J MGI:8433703
cx2
 		Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb/Gt(ROSA)26Sor+
Mtrfrem9Rwb/Mtrfrem9Rwb 		involves: C57BL/6J MGI:8433704


Genotype
MGI:8433703
hm1
Allelic
Composition		 Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb/Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb mutation (0 available); any Gt(ROSA)26Sor mutation (1212 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:370627 )
• Male and female body weights, optic nerves, sciatic nerves, motor and sensory branches of the femoral nerves, spinal cord, heart, liver, kidney, spleen, medial gastrocnemius, eye, and brain were all found to be normal




Genotype
MGI:8433704
cx2
Allelic
Composition		 Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb/Gt(ROSA)26Sor+
Mtrfrem9Rwb/Mtrfrem9Rwb
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb mutation (0 available); any Gt(ROSA)26Sor mutation (1212 available)
Mtrfrem9Rwb mutation (0 available); any Mtrfr mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to tooth bud stage, complete penetrance ( J:370627 )
• This transgenic expression of truncated human MTRFR fails to rescues the embryonic lethality caused by homozygosity of the K155* mutation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory