Phenotypes associated with this allele

• Allele Symbol: Smurf1^tm1.1Kry
• Allele Name: targeted mutation 1.1, Gerard Karsenty
• Allele ID: MGI:8420547
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smurf1^tm1.1Kry/Smurf1^tm1.1Kry	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J	MGI:8420559

Genotype
MGI:8420559

hm1

• Allelic Composition: Smurf1^tm1.1Kry/Smurf1^tm1.1Kry
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

enhanced osteoblast differentiation ( J:235082 )

homeostasis/metabolism

increased circulating insulin level ( J:235082 , J:235082 )

increased circulating osteocalcin level ( J:235082 )

• ~3x higher circulating undercarboxylated osteocalcin level

skeleton

enhanced osteoblast differentiation ( J:235082 )

abnormal clavicle morphology ( J:235082 )

• longer

increased osteoblast cell number ( J:235082 )

• at age 2 months

increased bone trabecula number ( J:235082 )

• at age 2 months

increased bone mass ( J:235082 )

• at age 2 months

premature sagittal suture closure ( J:235082 )

increased bone ossification ( J:235082 )

• at age 2 months