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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mtrfrem9Rwb
endonuclease-mediated mutation 9, Robert W Burgess
MGI:8407815
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mtrfrem9Rwb/Mtrfrem9Rwb C57BL/6J-Mtrfrem9Rwb/Rwb MGI:8407834
ht2
 		Mtrfrem9Rwb/Mtrfr+ C57BL/6J-Mtrfrem9Rwb/Rwb MGI:8407847
cx3
 		Gt(ROSA)26Sorem3.1(CAG-MTRFR)Rwb/Gt(ROSA)26Sor+
Mtrfrem9Rwb/Mtrfrem9Rwb 		involves: C57BL/6J MGI:8407861
cx4
 		Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb/Gt(ROSA)26Sor+
Mtrfrem9Rwb/Mtrfrem9Rwb 		involves: C57BL/6J MGI:8433704


Genotype
MGI:8407834
hm1
Allelic
Composition		 Mtrfrem9Rwb/Mtrfrem9Rwb
Genetic
Background		 C57BL/6J-Mtrfrem9Rwb/Rwb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtrfrem9Rwb mutation (0 available); any Mtrfr mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to tooth bud stage, complete penetrance ( J:370627 )
• fewer than normal homozygous embryos by E11.5 and none after that timepoint.




Genotype
MGI:8407847
ht2
Allelic
Composition		 Mtrfrem9Rwb/Mtrfr+
Genetic
Background		 C57BL/6J-Mtrfrem9Rwb/Rwb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtrfrem9Rwb mutation (0 available); any Mtrfr mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:8407861
cx3
Allelic
Composition		 Gt(ROSA)26Sorem3.1(CAG-MTRFR)Rwb/Gt(ROSA)26Sor+
Mtrfrem9Rwb/Mtrfrem9Rwb
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem3.1(CAG-MTRFR)Rwb mutation (0 available); any Gt(ROSA)26Sor mutation (1212 available)
Mtrfrem9Rwb mutation (0 available); any Mtrfr mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:370627 )
N
• This transgenic expression of wildtype human MTRFR partially rescues the embryonic lethality caused by homozygosity of the K155* mutation in that some homozygotes were born although less than half the number expected from a full rescue. Surviving homozygotes were found to be normal in all assessments including body weight, wire hang duration, sciatic nerve conduction velocity, peripheral nerve histology, retina, optic nerve, ratio of triceps surae weight to body weight, and no biomarker indication of integrated stress response.




Genotype
MGI:8433704
cx4
Allelic
Composition		 Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb/Gt(ROSA)26Sor+
Mtrfrem9Rwb/Mtrfrem9Rwb
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem4.1(CAG-MTRFR*)Rwb mutation (0 available); any Gt(ROSA)26Sor mutation (1212 available)
Mtrfrem9Rwb mutation (0 available); any Mtrfr mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to tooth bud stage, complete penetrance ( J:370627 )
• This transgenic expression of truncated human MTRFR fails to rescues the embryonic lethality caused by homozygosity of the K155* mutation




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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory