Phenotypes associated with this allele

• Allele Symbol: Mtrfr^em9Rwb
• Allele Name: endonuclease-mediated mutation 9, Robert W Burgess
• Allele ID: MGI:8407815
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtrfr^em9Rwb/Mtrfr^em9Rwb	C57BL/6J-Mtrfr^em9Rwb/Rwb	MGI:8407834
ht2	Mtrfr^em9Rwb/Mtrfr^+	C57BL/6J-Mtrfr^em9Rwb/Rwb	MGI:8407847
cx3	Gt(ROSA)26Sor^em3.1(CAG-MTRFR)Rwb/Gt(ROSA)26Sor^+ Mtrfr^em9Rwb/Mtrfr^em9Rwb	involves: C57BL/6J	MGI:8407861

Genotype
MGI:8407834

hm1

• Allelic Composition: Mtrfr^em9Rwb/Mtrfr^em9Rwb
• Genetic Background: C57BL/6J-Mtrfr^em9Rwb/Rwb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage, complete penetrance ( J:370627 )

• fewer than normal homozygous embryos by E11.5 and none after that timepoint.

Genotype
MGI:8407847

ht2

• Allelic Composition: Mtrfr^em9Rwb/Mtrfr⁺
• Genetic Background: C57BL/6J-Mtrfr^em9Rwb/Rwb

normal phenotype

no abnormal phenotype detected ( J:370627 )

Genotype
MGI:8407861

cx3

• Allelic Composition: Gt(ROSA)26Sor^{em3.1(CAG-MTRFR)Rwb}/Gt(ROSA)26Sor⁺; Mtrfr^em9Rwb/Mtrfr^em9Rwb
• Genetic Background: involves: C57BL/6J

mortality/aging

mortality/aging ( J:370627 )

N • The expression of human wild type MTRFR allowed homozygous Mtrfr mutant mice to survive when normally they die before E12.5.