reproductive system
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• sperm analysis in two males shows a high mobility rate
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• sperm analysis in two males shows high sperm cell count
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• females are more fertile than controls, with an average delivery of 8.17 pups compared to 5.38 pups for wild-type controls
• however, males show normal fertility and testes phenotype and show complete spermatogenesis
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immune system
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• splenic T cells exhibit higher proliferation index at 72 hours of stimulation with anti-CD3/anti-CD28 antibodies
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• thymus hyperplasia with cell hyperactivation in the cortical zone
• however, no difference in T cell sub-population distribution is seen in the thymus at 6 weeks of age
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• splenic white pulp hyperplasia
• however, no difference in T cell sub-population distribution is seen in the spleen at 6 weeks of age
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• splenic white pulp hyperplasia
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hematopoietic system
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• splenic T cells exhibit higher proliferation index at 72 hours of stimulation with anti-CD3/anti-CD28 antibodies
|
|
• thymus hyperplasia with cell hyperactivation in the cortical zone
• however, no difference in T cell sub-population distribution is seen in the thymus at 6 weeks of age
|
|
• splenic white pulp hyperplasia
• however, no difference in T cell sub-population distribution is seen in the spleen at 6 weeks of age
|
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• splenic white pulp hyperplasia
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growth/size/body
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• splenic white pulp hyperplasia
• however, no difference in T cell sub-population distribution is seen in the spleen at 6 weeks of age
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endocrine/exocrine glands
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• thymus hyperplasia with cell hyperactivation in the cortical zone
• however, no difference in T cell sub-population distribution is seen in the thymus at 6 weeks of age
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cellular
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• sperm analysis in two males shows a high mobility rate
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• splenic T cells exhibit higher proliferation index at 72 hours of stimulation with anti-CD3/anti-CD28 antibodies
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