All Phenotypes Prkg1<tm1.1Rbp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkg1^tm1.1Rbp/Prkg1^tm1.1Rbp	involves: 129S1/SvImJ * 129S4/SvJaeSor	MGI:8403028
ht2	Prkg1^tm1.1Rbp/Prkg1⁺	involves: 129S1/SvImJ * 129S4/SvJaeSor	MGI:8403040
ht3	Prkg1^tm1.1Rbp/Prkg1⁺	involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6NHsd	MGI:8403042

Allelic Composition	Prkg1^tm1.1Rbp/Prkg1^tm1.1Rbp
Genetic Background	involves: 129S1/SvImJ * 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkg1^tm1.1Rbp mutation (0 available); any Prkg1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

enlarged esophagus ( J:279420 )

• in mice that die by age 6 weeks

dilated intestine ( J:279420 )

• in mice that die by age 6 weeks

enlarged stomach ( J:279420 )

• in mice that die by age 6 weeks

growth/size/body

enlarged esophagus ( J:279420 )

• in mice that die by age 6 weeks

decreased body size ( J:279420 )

• in surviving mice

decreased body weight ( J:279420 )

• in surviving mice

mortality/aging

lethality, incomplete penetrance ( J:279420 )

• 50% die by age 6 weeks from gastro-intestinal dysfunction, with dilated esophagus, stomach, and bowel

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:279420 , J:347789 , J:347789 )

N	• normal heart rate and pulse pressure (J:279420)
N	• normal heart to body weight ratio, left ventricular (LV) mass, interventricular septal thickness, fractional shortening and left ventricle internal diameters in diastole and systole at age 4 and 12 months (J:347789)
N	• normal heart to body weight ratio, left ventricular (LV) mass, interventricular septal thickness, fractional shortening and left ventricle internal diameters in diastole and systole at age 4 months (J:347789)

abnormal aorta tunica media morphology ( J:279420 )

• normal at age 4-6 months

• collagen accumulation at age 12 months

• normal thickness at age 4-6 and 12 months

abnormal aorta elastic fiber morphology ( J:279420 )

• normal at age 4-6 months

• fiber breaks at age 12 months

abnormal aorta smooth muscle morphology ( J:279420 )

• apoptosis and cell loss at age 12 months

• normal at age 4-6 months

dilated aorta ( J:279420 )

• at age 12 months

• normal aorta dimensions at age 4-6 months

thin interventricular septum ( J:347789 )

• at age 12 months

decreased heart left ventricle weight ( J:347789 )

• at age 12 months

decreased heart left ventricle wall thickness ( J:347789 )

• at age 12 months

cardiac interstitial fibrosis ( J:347789 )

• at age 12 months

• normal at age 4 months

decreased systemic arterial blood pressure ( J:279420 )

• slightly lower systolic and diastolic blood pressure during sleep and wake cycles

cellular

cardiac interstitial fibrosis ( J:347789 )

• at age 12 months

• normal at age 4 months

increased cardiomyocyte apoptosis ( J:347789 )

• at age 12 months

• normal at age 4 months

muscle

abnormal aorta smooth muscle morphology ( J:279420 )

• apoptosis and cell loss at age 12 months

• normal at age 4-6 months

increased cardiomyocyte apoptosis ( J:347789 )

• at age 12 months

• normal at age 4 months

Allelic Composition	Prkg1^tm1.1Rbp/Prkg1⁺
Genetic Background	involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6NHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkg1^tm1.1Rbp mutation (0 available); any Prkg1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cardiac interstitial fibrosis ( J:347789 )

• after transverse aortic constriction (TAC) at age 4 months

increased cardiomyocyte apoptosis ( J:347789 )

• after transverse aortic constriction (TAC) at age 4 months

cardiovascular system

cardiovascular system phenotype ( J:347789 )

N	• normal increase in left ventricle posterior wall thickness after transverse aortic constriction (TAC) at age 4 months

thoracic aorta aneurysm ( J:279420 )

• transverse aortic constriction (TAC)-induced aortic rupture in 36% of mice at age 4 months

myocardium hypertrophy ( J:347789 )

• increased cardiomyocyte size after transverse aortic constriction (TAC) at age 4 months

increased heart weight ( J:347789 )

• after transverse aortic constriction (TAC) at age 4 months

increased heart left ventricle weight ( J:347789 )

• after transverse aortic constriction (TAC) at age 4 months

cardiac interstitial fibrosis ( J:347789 )

• after transverse aortic constriction (TAC) at age 4 months

growth/size/body

myocardium hypertrophy ( J:347789 )

• increased cardiomyocyte size after transverse aortic constriction (TAC) at age 4 months

increased heart weight ( J:347789 )

• after transverse aortic constriction (TAC) at age 4 months

muscle

myocardium hypertrophy ( J:347789 )

• increased cardiomyocyte size after transverse aortic constriction (TAC) at age 4 months

increased cardiomyocyte apoptosis ( J:347789 )

• after transverse aortic constriction (TAC) at age 4 months

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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