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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itga4em1Jifc
endonuclease-mediated mutation 1, JianFeng Chen
MGI:8402600
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itga4em1Jifc/Itga4em1Jifc Not Specified MGI:8402971


Genotype
MGI:8402971
hm1
Allelic
Composition		 Itga4em1Jifc/Itga4em1Jifc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga4em1Jifc mutation (0 available); any Itga4 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell number ( J:278096 )
• impaired T cell distribution in peripheral lymph nodes (PLNs) after oral Salmonella typhimurium administration
• normal T cell distribution in mesenteric lymph nodes (MLNs) and Peyers patches (PPs) after oral Salmonella typhimurium administration
abnormal T cell physiology ( J:278096 )
• failure of thermally stressed (40C) T cells to increase sticking fraction in order IV and V venules and increase the homing to inguinal lymph nodes
• normal increase in sticking fraction of T cells in order IV and V venules and increase in homing to inguinal lymph nodes at body temperature

immune system
abnormal T cell number ( J:278096 )
• impaired T cell distribution in peripheral lymph nodes (PLNs) after oral Salmonella typhimurium administration
• normal T cell distribution in mesenteric lymph nodes (MLNs) and Peyers patches (PPs) after oral Salmonella typhimurium administration
abnormal T cell physiology ( J:278096 )
• failure of thermally stressed (40C) T cells to increase sticking fraction in order IV and V venules and increase the homing to inguinal lymph nodes
• normal increase in sticking fraction of T cells in order IV and V venules and increase in homing to inguinal lymph nodes at body temperature
increased susceptibility to bacterial infection induced morbidity/mortality ( J:278096 )
• increased lethality after oral Salmonella typhimurium administration
• increased intestinal tissue damage after oral Salmonella typhimurium administration

mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:278096 )
• increased lethality after oral Salmonella typhimurium administration
• increased intestinal tissue damage after oral Salmonella typhimurium administration




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/08/2026
MGI 6.24 		The Jackson Laboratory